- Squamous Cell Carcinoma of the Cervix with Intraepithelial Extension to the Endometrium: A Case Report.
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Bohng Hee Kim
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Korean J Pathol. 2007;41(2):135-137.
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- Squamous cell carcinoma (SCC) of the cervix with intraepithelial extension to the endometrium is a rare event, accounting for about 0.7% of all cervical SCC.
Endometrial lesion has been considered as a direct extension of cervical cancer in the early reports, and this was confirmed in a recent molecular study. I report here on the case of a 56-year-old woman who had stage IIB SCC of the cervix with extension, in an in situ fashion, to the entire endometrium. HPV type 16 was detected via PCR in both the cervical and endometrial tumors.
- Pure Immature Teratoma with Increase of Serum alpha-fetoprotein: A Case Report.
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Bohng Hee Kim
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Korean J Pathol. 2007;41(1):63-65.
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- In the immature teratoma with increased serum alpha-fetoprotein (AFP), a complete pathologic examination is especially required because coexistence with other germ cell tumors is associated with a poor prognosis. If the case is proved to be a pure immature teratoma in spite of a thorough examination, the source of AFP should be found as an AFP-producing pure immature teratoma is not associated with a poor prognosis. In this case of a grade III-immature teratoma in an ovary of a 12-year old girl, serum AFP was increased. On pathologic examination, there was no evidence of a yolk sac tumor or embryonal carcinoma. On an AFP immunohistochemical stain, immature liver tissue, digestive and respiratory epitheliums were positive.
- Cytologic Features of Villoglandular Adenocarcinoma of the Uterine Cervix : A Report of Two Cases.
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Bohng Hee Kim
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Korean J Cytopathol. 2006;17(2):136-142.
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- Villoglandular adenocarcinoma of uterine cervix has recently been described, and is characterized by good prognosis and occurrence in young women, except a small number of cases.
Morphologically, it exclusively shows villoglandular growth and mild to moderate nuclear atypia, the cytologic diagnoses have been frequently missed due to interpretation error. We report here on the cytologic findings of two cases, and both cases were not diagnosed as adenocarcinoma before punch biopsy. One of these cases showed previously described characteristic features such as high cellularity and large tissue fragments with long villous fronds lined by columnar cell with mild nuclear atypia. The other showed moderate cellularity of somewhat smaller clusters without long villous structures. The clusters showed marked nuclear overlapping and the nuclei showed distinct moderate atypia with hyperchromasia and coarse chromatin pattern. The nucleoli were indistinct. Recognition of these features will be helpful to avoid underdiagnosis as a benign lesion, although diagnosis is still difficult in a portion of the cases.
- The Usefulness of Fine Needle Aspiration Cytology of Bone Lesions.
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Bohng Hee Kim, Gyung Yub Gong
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Korean J Cytopathol. 2002;13(2):51-59.
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- To determine the usefulness of fine needle aspiration cytology(FNAC) of bone lesions and the complementary role of FNAC and percutaneous needle biopsy, 75 cases of FNAC taken from bone lesions were analyzed. Correlations with histopathology were possible in 47 cases, including 14 cases of simultaneous core biopsy and 33 cases of subsequent open biopsy due to inadequate aspirates. Among 75 cases, 4 cases were benign tumors and tumor-like lesion, 11 cases were malignant primary bone tumors, 17 cases were metastatic tumors, and 43 cases were nonneoplastic bone lesions. The aspirates were adequate in 35 cases(46.7%), in all of which the discrimination between benignancy and malignancy was possible. The main reason for inadequate aspirates was due to hypocellularity. In the cases of aspiration and core biopsy simultaneously done, the diagnostic accuracy of aspiration, core biopsy, and both were 57%(8/14), 78.6%(11/14), and 92.9%(13/14), respectively. We conclude that a final diagnosis based on cytology is possible with the adequate aspirates and the clinical and radiological findings. Also we confirm the complementary role between FNAC and core biopsy in bone lesions.
- A Cytomorphologic Study of Benign and Malignant Papillary Neoplasms of the Breast.
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Ho Jung Lee, Gyungyub Gong, Bohng Hee Kim, Sei Hyun Ahn, Jeong Mi Park, Jooryung Huh, Shin Kwang Khang, Jae Y Ro
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Korean J Cytopathol. 1999;10(1):27-34.
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- Benign and malignant papillary neoplasms of the breast may be difficult to distinguish in both cytologic and histologic preparations.
To define the cytologic features of benign and malignant papillary lesions, we retrospectively reviewed 18 cases of fine needle aspirates from histologically confirmed cases of papilloma or papillary carcinoma of the breast. This study included 3 intraductal papillary carci nomas, 3 invasive papillary carcinomas, and 12 intraductal papillomas. All cases were evaluated for presence or absence of papillary fragments, bloody background, apocrine metaplasia, macrophages, and degree of cellularity, atypia, and single isolated columnar epithelial cells. Papillary fragments were present in all cases. The background of the smear was bloody in all 6 carcinomas, but in only 7 out of 12 papillomas. Markedly increased cellularity was present in 4 carcinomas(67%) and 7 papillomas(58%). Single cells were present in 5 carcinomas(83%) and 8 papil lomas(67%). The majority of papillomas and papillary carcinomas had mild to moderate atypia, and severe atypia was noted in one case of intraductal papillary carcinoma and one case of invasive papillary carcinoma.
Apocrine metaplasia was absent in all cases of papillary carcinomas, but present in 8 papillomas(67%).
Macrophages were noted in 4 carcinomas and were present in all cases of papillomas. The constellation of severe atypia, bloody background, absence of apocrine metaplasia and/or macrophages were features to favor carcinoma.
Malignant lesions tended to show higher cellularity and more single isolated cells.
The cytologic features mentioned above would be helpful to distinguish benign from malignant papillary lesions of the breast. However, because of overlapping of cytologic features, surgical excision should be warranted in all cases of papillary lesions of the breast to further characterize the tumor.
- Bizarre Parosteal Osteochondromatous Proliferation: A report of five cases.
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Bohng Hee Kim, Yong Koo Park, Youn Wha Kim, Moon Ho Yang
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Korean J Pathol. 1996;30(8):733-738.
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- Bizarre parosteal osteochondromatous proliferation was first described in 1983, when Nora and his collegues reported 35 examples of a proliferative lesion involving bones of the hands and the feet. In 1993, Meneses reported 65 cases of this condition. A fourth of all the reported cases involved the long bones. It is important to identify the clinical, roentgenographic, and histologic characteristic to seperate it from other entities because it is a benign lesion with atypical microscopic features with a tendency to recur.
Roentgenograms show a calcific mass attached to the underlying cortex having a broad base. Histologically, the lesion exhibites proliferative activity, irregular bony cartilaginous interfaces, and enlarged, bizarre, and binucleated chondrocytes. We reviewed the bone tumors, diagnosed in the KyungHee University Hospital, dated from 1984 to 1994. Five cases were revised to Nora's lesion, all of which were previously diagnosed as osteochondroma. The ages of the patients ranged from 12 to 57 years (median, 19 years), and all of them were males. Two cases involved the bones of hands and feet (metacarpal and talus), and 3 cases involved the long bones (humerus, fibula, and ulna). One lesion involving the humerus has a recurrence. No metastasis had been reported.
- Cytopathology of Hurthle Cell Adenoma: A Cese Report by Fine Needle Aspiration.
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Bohng Hee Kim, Myoung Suk Kang, Jae Hoon Park, Youn Wha Kim, Yong Ku Park, Ju Hie Lee, Moon Ho Yang
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Korean J Cytopathol. 1995;6(2):193-198.
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- The increased use of thyroid fine needle aspiration (FNA) has refocused on Hurthle cell lesions. The cytologic diagnosis of Hurthle cell tumor is a challenge due to the presence of Hurthle cells in non-neoplastic lesions and the inability to differentiate between benign and malignant Hurthle cell tumor. We report a case of Hurthle cell adenoma(HCA) in a 68-year old woman, with reivew of the cytopathologic findings. FNA revealed losely cohesive or sheets of sheets of large oval to polygonal Hurthle cells containing bundant granular cytoplasm. The histopathologic examination confirmed the diagnosis of HCA with follicular growth pattern, Ultrastructurally, the cytoplasm was packed with variable sized mitochondria.
- Cytologic Features of Papnicolaou Smears of Malignant Melanoma Arising in Vagina: A Cese Report.
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Myung Suk Kang, Bohng Hee Kim, Jae Hoon Park, Youn Wha Kim, Yong Koo Park, Ju Hie Lee, Moon Ho Yang
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Korean J Cytopathol. 1995;6(2):209-214.
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- Primary malignant melanoma of vagina is a rare tumor which is easily misinterpretated in routine cytologic examination.
We lately experienced a case of primary malignant melanoma of the vagina with direct cervical extension diagnosed by Pap smear. The cervicovaginal smear showed variable sized clusters of epithelial cells or singly scattered abnormal epithelial cells. Most of the tumor cells had round hyperchromatic nuclei with prominent nucleoli and brownish pigments in cytoplasm. The cytologic findings are compared with histologic features of resected specimen.
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